Thursday, Aug. 28, 2014
79 ° Fair
|Student||Rachel A Francher|
Dr. Anthony Hayford|
|Course||CHEM 489: Research in the Natural Sciences|
Benzoindolizines are a class of heterocyclic compounds that have several medicinal applications in the area of pharmaceuticals. The synthesis of benzoindolizines can be used for the production of therapeutic drugs for tuberculosis and some types of cancers. One common method for synthesizing benzoindolizines is the 1, 3 dipolar cycloaddition of ylides. In our research, we have successfully used the 1, 6 conjugate (Michael) addition to combine methylene carbanions with quinoline vinylacetylines to produce benzoindolizines. Various methylene carbanions such as malononitrile and ethyl cyanoacetate have yielded simple analogues of highly functionalized benzoindolizines when added to the silyated quinoline.